Table 3

Effects of equieffective doses of fluoxetine, Ro 60-0175/ORG 35030 and Ro 60-0332/ORG 35035 on behavioral parameters in a plus-maze task in rats

First Treatment Injection
Treatment (i.p.)Time (s) Spent in Open ArmsOpen Arms EnteredClosed Arms EnteredAttempts
Vehicle31.6  ± 5.93.3  ± 0.69.6  ± 0.66.2  ± 0.5
Fluoxetine5.5  ± 2.1**0.8  ± 0.2**7.6  ± 1.05.6  ± 0.7
Ro 60-0175 (ORG 35030)33.4  ± 9.13.7  ± 0.98.2  ± 0.84.9  ± 0.8
Ro 60-0332 (ORG 35035)20.3  ± 7.01.4  ± 0.53-150 4.4  ± 1.1***3.8  ± 0.83-150
Final Treatment Injection
Treatment (i.p.)Time (s) Spent in Open ArmsOpen Arms EnteredClosed Arms EnteredAttempts
Vehicle18.3  ± 6.91.7  ± 0.66.3  ± 1.34.6  ± 1.1
Fluoxetine1.1  ± 0.73-150 0.3  ± 0.23-150 7.5  ± 1.34.9  ± 0.8
Ro 60-0175 (ORG 35030)15.3  ± 6.31.8  ± 0.68.1  ± 1.34.5  ± 0.9
Ro 60-0332 (ORG 35035)8.0  ± 5.10.7  ± 0.44.4  ± 1.03.5  ± 0.8
  • 3-150  P < .05; ** P < .01; ***P < .001 for comparison with vehicle condition.