First Treatment Injection | ||||
---|---|---|---|---|
Treatment (i.p.) | Time (s) Spent in Open Arms | Open Arms Entered | Closed Arms Entered | Attempts |
Vehicle | 31.6 ± 5.9 | 3.3 ± 0.6 | 9.6 ± 0.6 | 6.2 ± 0.5 |
Fluoxetine | 5.5 ± 2.1** | 0.8 ± 0.2** | 7.6 ± 1.0 | 5.6 ± 0.7 |
Ro 60-0175 (ORG 35030) | 33.4 ± 9.1 | 3.7 ± 0.9 | 8.2 ± 0.8 | 4.9 ± 0.8 |
Ro 60-0332 (ORG 35035) | 20.3 ± 7.0 | 1.4 ± 0.53-150 | 4.4 ± 1.1*** | 3.8 ± 0.83-150 |
Final Treatment Injection | ||||
---|---|---|---|---|
Treatment (i.p.) | Time (s) Spent in Open Arms | Open Arms Entered | Closed Arms Entered | Attempts |
Vehicle | 18.3 ± 6.9 | 1.7 ± 0.6 | 6.3 ± 1.3 | 4.6 ± 1.1 |
Fluoxetine | 1.1 ± 0.73-150 | 0.3 ± 0.23-150 | 7.5 ± 1.3 | 4.9 ± 0.8 |
Ro 60-0175 (ORG 35030) | 15.3 ± 6.3 | 1.8 ± 0.6 | 8.1 ± 1.3 | 4.5 ± 0.9 |
Ro 60-0332 (ORG 35035) | 8.0 ± 5.1 | 0.7 ± 0.4 | 4.4 ± 1.0 | 3.5 ± 0.8 |
↵3-150 P < .05; ** P < .01; ***P < .001 for comparison with vehicle condition.