Table 2

Binding affinity (pKi) for 5-HT receptors

Receptor (species)Ro 60-0175 (ORG 35030)Ro 60-0332 (ORG 35035)
5-HT1A(human)5.45.7
5-HT1B(rat)5.3n.d.
5-HT1D (human)5.77.4
5-HT2A (human)7.57.0
5-HT2C(human)9.08.5
5-HT3 (rat)5.2<5
5-HT4 (guinea pig)5.7n.d.
5-HT6 (human)5.26.2
5-HT7(human)5.65.8
  • n.d. = not determined.