Pharmacokinetic parameters obtained by noncompartmental analysis in rabbits after oral administration of 1 mg/kg EE alone (control) and in the presence of fiber A or B
| Parameters | Control | Fiber A | Fiber B |
|---|---|---|---|
| λ (min−1) | 0.0181 ± 0.0053 | 0.0177 ± 0.0030 | 0.0179 ± 0.0029 |
| AUCt−∞ (ng · min · ml−1) | 7.094 ± 5.041 | 11.156 ± 4.920 | 10.519 ± 7.772 |
| AUC0−∞ (ng · min · ml−1) | 628.668 ± 136.765 | 436.580 ± 67.7022-a | 418.596 ± 110.7722-a |
| Cl (l · kg−1 · min−1) | 1.660 ± 0.403 | 2.337 ± 0.334 | 2.532 ± 0.6862-a |
| t 1/2λ (min) | 40.432 ± 9.006 | 40.004 ± 6.665 | 39.502 ± 6.469 |
| C max (ng · ml−1) | 16.328 ± 3.622 | 11.348 ± 2.2012-a | 10.608 ± 3.3112-a |
| t max(min) | 10.00 — | 10.00 — | 10.00 — |
Values are means ± S.D.
Cl, total body clearance.
↵2-a Significant difference from control at P ≤ .05.