Drug | Respirationb,c,d | Heart Rate1-e | |||||||
---|---|---|---|---|---|---|---|---|---|
Antinociception1-a | Air | 5% CO2 | |||||||
50°C | 55°C | f | Vt | Ve | f | Vt | Ve | ||
Delta-9-THC | 1.8 ± 0.2 | 1.2 ± 0.1 | 25 ± 2 | 112 ± 20 | 2688 ± 337 | 36 ± 4 | 191 ± 7 | 6920 ± 576 | 204 ± 7 |
WIN 55212 | 1.5 ± 0.1 | 0.9 ± 0.1 | 26 ± 2 | 116 ± 10 | 2986 ± 412 | 34 ± 2 | 180 ± 9 | 6359 ± 402 | 191 ± 4 |
Heroin | 1.7 ± 0.1 | 0.9 ± 0.1 | 25 ± 1 | 110 ± 20 | 2741 ± 510 | 36 ± 4 | 186 ± 13 | 6684 ± 352 | 216 ± 8 |
U 69593 | 1.3 ± 0.1 | 1.0 ± 0.1 | 28 ± 3 | 102 ± 6 | 2843 ± 224 | 37 ± 1 | 190 ± 14 | 7071 ± 462 | 228 ± 2 |
Overall Mean | 1.6 ± 0.1 | 1.0 ± 0.1 | 26 ± 1 | 110 ± 3 | 2815 ± 66 | 36 ± 1 | 187 ± 2 | 6786 ± 155 | 210 ± 8 |