Table 2

Effect of a challenge injection of cocaine or GBR12783 (40 mg/kg) on stereotyped behavior

ChallengeStereotypy scoresAverage cumulative rating (0–30 min)
0–15 min15–30 min
Saline0.69  ± 0.110.27  ± 0.070.96  ± 0.15
Cocaine (40 mg/kg)2.36  ± 0.242-a 3.5  ± 0.212-a 5.86  ± 0.432-a
GBR12783 (40 mg/kg)2.69  ± 0.12b 3.59  ± 0.22b 6.28  ± 0.33b
  • Means ± S.E.M. of 11 to 13 rats per group.

  • 2-a P < .01, b P ≤ .001, compared with the saline-challenged group.