Table 1

IC50 Values for Inhibition of Colon Carcinoma Cell Growth and TPα Cross-linking by NSAIDs

NSAIDIC50 (μM)
TPα cross-linking1-aCell growth1-b
Acetaminophen*>1000021000  ± 14000
Aspirin*9300  ± 47001770  ± 640
Diclofenac*160  ± 90120  ± 110
Diflunisal80  ± 30160  ± 80
Ibuprofen*2300  ± 600290  ± 160
Indomethacin*150  ± 40200  ± 130
Meclofenamate90  ± 50120  ± 70
Mefenamate220  ± 60200  ± 60
Naproxen*1200  ± 400660  ± 460
Niflumate290  ± 180130  ± 100
Phenylbutazone2200  ± 400600  ± 180
Piroxicam2600  ± 500690  ± 390
Salicylate*3300  ± 14001750  ± 400
Sulindac Sulfide*40  ± 10190  ± 180
Sulindac Sulfoxide*580  ± 260660  ± 520
Sulindac Sulfone*280  ± 10580  ± 140
Tiaprofenate1400  ± 400440  ± 230
Tolmetin1400  ± 1001900  ± 170

  • ↵1-a IC50 values (mean ± S.D.,n ≥ 3) for inhibition of cross-linking of125I-[Nle15]-gastrin2,17 to TPα were determined as described in “Materials and Methods.”

  • ↵1-b IC50 values (mean ± S.D., n ≥ 3) for inhibition of growth of LIM 1215 colon carcinoma cells by NSAIDs were determined as described in “Materials and Methods.” The values for the NSAIDs marked with an asterisk have been reported previously (Murphy et al., 1998). Similar values have been reported for the human colon carcinoma cell lines HT 29, SW 480 and DLD-1 by Hixson and coworkers (Hixson et al., 1994).