Table 1

Content of mononamines in the brain of mice treated with AMPT, 6-OHDA and DSP-41-a

TreatmentnNADA5-HT
ng/g wet tissue
Prefrontal cortex
 Control6327.9  ± 22.150.3  ± 8.5450.3  ± 32.5
 PCP7326.7  ± 13.469.0  ± 20.9417.9  ± 31.0
 AMPT (100 mg/kg)6255.2  ± 29.220.4  ± 6.3*438.9  ± 19.8
 Control6337.7  ± 21.675.5  ± 2.7399.8  ± 50.0
 PCP6277.0  ± 26.978.1  ± 9.1355.6  ± 66.8
 6-OHDA (100 μg/mouse)8233.6  ± 47.721.4  ± 4.2**431.2  ± 22.1
 Control6366.1  ± 8.157.7  ± 6.3415.1  ± 14.8
 PCP6395.7  ± 6.869.7  ± 24.0403.5  ± 21.0
 DSP-4 (30 mg/kg)7125.3  ± 22.4**50.7  ± 5.8413.0  ± 17.5
Striatum
 Control6167.5  ± 23.210753.9  ± 1170.2431.9  ± 54.6
 PCP7183.9  ± 20.910291.4  ± 463.2542.8  ± 26.4
 AMPT (100 mg/kg)6136.1  ± 25.46829.4  ± 838.7*527.8  ± 59.6
 Control6209.6  ± 35.39637.7  ± 1137.8419.2  ± 63.5
 PCP6152.6  ± 27.18704.6  ± 727.6407.9  ± 40.0
 6-OHDA (100 μg/mouse)8113.4  ± 23.94910.8  ± 655.2**461.7  ± 22.9
 Control6201.8  ± 22.99794.6  ± 752.0514.1  ± 71.2
 PCP6189.5  ± 13.312113.9  ± 532.1528.6  ± 118.7
 DSP-4 (30 mg/kg)784.7  ± 15.9**9407.7  ± 451.4435.2  ± 29.8

  • ↵1-a Values are expressed as the mean ± S.E.M. * P < .05, ** P < .01 vs. control group.