ED3°C values (in mg/kg) and Emax values (in °C) (±95% confidence limits) for SNC80 administered either alone or after pretreatment with naltrindole (1.0 mg/kg), quadazocine (0.1 mg/kg) or BW373U86 (0.56–1.0 mg/kg) in the warm-water tail-withdrawal assay of antinociception
| Treatment | ED3°C | Emax |
|---|---|---|
| SNC80 alone | 0.93 (0.41–2.1) | 4.1 (3.9–4.1) |
| + 1.0 Naltrindole | 152-a (9.2–23) | 3.7 (3.0–4.5) |
| + 0.1 Quadazocine | 1.5 (0.82–2.7) | 4.0 (3.9–4.1) |
| + 0.56 BW373U86 | 3.2 (1.6–6.1) | 4.0 (3.9–4.1) |
| + 1.0 BW373U86 | 122-a (8.3–17) | 3.7 (3.0–4.4) |
↵2-a Significantly different from agonist alone as determined by nonoverlapping confidence limits.