Effects of alendronate on dry bone weight, bone volume, ash weight and Ca content of the tibia from ovariectomized rats
| Group | n | Dry Weight (mg) | Volume (ml) | Ash Weight (mg) | Ca (mg) | Ca/Pi | Dry Wt./Vol. (g/ml) | Ca/Vol. (mg/ml) |
|---|---|---|---|---|---|---|---|---|
| Sham | 12 | 389.6 ± 27.6 | 0.31 ± 0.03* | 238.1 ± 16.2 | 78.3 ± 5.2 | 1.88 | 1.24 ± 0.04* | 201.1 ± 5.8 |
| OVX | 12 | 404.0 ± 20.9 | 0.35 ± 0.02 | 244.6 ± 12.1 | 79.8 ± 3.9 | 1.92 | 1.16 ± 0.04 | 197.7 ± 4.1 |
| Alendronate | ||||||||
| 0.04 mg/kg | 8 | 417.5 ± 36.7 | 0.35 ± 0.03 | 256.7 ± 16.2 | 91.4 ± 6.6 | 1.99 | 1.18 ± 0.03 | 219.3 ± 6.3* |
| 0.2 mg/kg | 8 | 416.4 ± 21.8 | 0.35 ± 0.02 | 256.2 ± 12.2 | 91.7 ± 4.5* | 1.98 | 1.21 ± 0.03 | 220.3 ± 5.0* |
| 1.0 mg/kg | 7 | 446.4 ± 32.1 | 0.36 ± 0.02 | 272.0 ± 23.6 | 98.1 ± 7.1* | 2.00 | 1.23 ± 0.02 | 219.7 ± 7.2* |
| 5.0 mg/kg | 7 | 478.3 ± 37.3* | 0.37 ± 0.02 | 298.3 ± 24.8* | 106.9 ± 8.7 | 2.03 | 1.30 ± 0.05* | 223.4 ± 4.4* |
| Pamidronate | ||||||||
| 0.2 mg/kg | 8 | 411.7 ± 35.7 | 0.36 ± 0.03 | 292.5 ± 107.8* | 91.0 ± 7.2 | 1.97 | 1.16 ± 0.03 | 221.2 ± 3.1* |
| 1.0 mg/kg | 7 | 416.2 ± 48.7 | 0.36 ± 0.04 | 254.0 ± 29.5 | 94.8 ± 9.3 | 2.09 | 1.18 ± 0.18 | 231.1 ± 39.1* |
| 5.0 mg/kg | 8 | 416.6 ± 35.5 | 0.34 ± 0.03 | 262.0 ± 23.8 | 92.2 ± 7.3 | 1.97 | 1.24 ± 0.05 | 221.0 ± 9.4* |
| Etidronate | ||||||||
| 5.0 mg/kg | 8 | 402.6 ± 36.8 | 0.35 ± 0.03 | 246.0 ± 23.2 | 87.9 ± 7.1 | 1.98 | 1.17 ± 0.03 | 218.6 ± 3.3* |
| 25.0 mg/kg | 8 | 425.6 ± 27.8 | 0.36 ± 0.03 | 261.9 ± 16.3 | 91.8 ± 5.2 | 1.99 | 1.18 ± 0.03 | 215.9 ± 3.8* |
| 125.0 mg/kg | 8 | 440.8 ± 46.8 | 0.39 ± 0.03* | 268.5 ± 31.2 | 91.8 ± 9.9 | 1.93 | 1.12 ± 0.04 | 208.3 ± 4.6* |
Data are mean ± S.D. * P < .05 (vs. OVX group) by Dunnett’s two-tailed test.