Species | n | Dose (mg/kg) | AUCoral (ng · hr/ml) | CLoral (ml/min/kg) | Cmax (ng/ml) | F (%) |
---|---|---|---|---|---|---|
Rat | 3 | 1.01-a | 5.0 | 3330 | 9.3 | 3.4 |
3 | 3.0 | 22.2 | 2252 | 33.9 | 5.0 | |
3 | 10.0 | 333 | 501 | 819.0 | 22.3 | |
Dog | 3 | 1.01-a | 87.7 (17.0) | 205 (39) | 39.3 (7.1) | 16.1 (2.5) |
3 | 3.0 | 316 (104) | 158 (47) | 129 (34) | 19.0 (5.1) | |
3 | 10.0 | 1041 (320) | 160 (46) | 559 (135) | 18.7 (4.3) | |
Human1-c | 6 | 5.01-b | 117 (16) | 11.1 (1.3) | 19.8 (2.1) | |
6 | 10.0 | 180 (32) | 13.2 (1.2) | 35.3 (4.3) | ||
6 | 20.0 | 408 (44) | 11.7 (0.8) | 68.1 (5.3) | ||
6 | 40.0 | 1010 (132) | 9.4 (1.3) | 151 (10) | ||
5 | 60.0 | 1482 (166) | 9.6 (1.1) | 266 (11) |