sGC Inhibitor or K+ Channel Inhibitors | Maximum Relaxation (%) | |||
---|---|---|---|---|
GEA 3268 (10 μM) | GEA 5145 (10 μM) | SIN-1 (33 μM) | SNAP (100 μM) | |
Control | 55.6 ± 5.2 | 67.9 ± 4.9 | 44.6 ± 4.1 | 40.5 ± 4.0 |
ODQ | ||||
1 μM | 32.2 ± 6.4** | 22.9 ± 2.6*** | 6.7 ± 1.7*** | 10.9 ± 2.7*** |
33 μM | 15.9 ± 2.4*** | 19.6 ± 2.9*** | 5.5 ± 2.5*** | 6.0 ± 2.1*** |
Glibenclamide 33 μM | 74.4 ± 4.5** | 77.8 ± 7.4 | 47.3 ± 4.6 | 43.9 ± 2.4 |
IbTX | ||||
33 nM | 42.5 ± 5.9 | 45.6 ± 6.2* | 25.6 ± 3.0** | 24.1 ± 4.6** |
100 nM | 35.5 ± 12.6* | 56.1 ± 2.1 | 19.2 ± 2.2** | 22.3 ± 1.8** |
ChTX | ||||
33 nM | 60.9 ± 3.5 | 57.8 ± 4.3 | 55.4 ± 4.3 | 37.0 ± 7.0 |
100 nM | 49.7 ± 3.8 | 55.5 ± 3.7 | 30.3 ± 1.7* | 27.8 ± 2.4* |