% Increase of cyclic GMP | |
---|---|
NMDA | 83.2 ± 5.3 (9) |
NMDA + trazodone | 4.7 ± 2.0 (9)*** |
NMDA + trazodone + mesulergine (0.01 μM) | 75.0 ± 5.9 (5) |
NMDA + trazodone + spiperone (0.3 μM) | 9.8 ± 3.2 (3)*** |
NMDA + trazodone + rauwolscine (0.3 μM) | 7.5 ± 4.3 (3)*** |
↵1-a Mean ± S.E.M. values of n experiments in triplicate are presented. Trazodone (0.01 μM) was added concomitantly with 0.1 μM NMDA; antagonists were added 15 min before. Other experimental details are given in “Methods.” Results are expressed as percent increase of cyclic GMP levels compared with the control values. ***Significantly different (P < .001) from NMDA.