Drug and derivative | Smax (%)2-a | SC502-b(μM) | Smax/SC50 |
---|---|---|---|
Fenofibric acid | 142 ± 25 | 8 ± 2 | 17.8 |
Clinofibrate | 89 ± 11 | 7 ± 2 | 12.7 |
Bezafibrate | 102 ± 20 | 15 ± 3 | 6.8 |
Clofibric acid | 150 ± 21 | 50 ± 5 | 3.0 |
2-(4-Chlorophenoxy)propionic acid | 117 ± 12 | 140 ± 20 | 0.84 |
2-Phenoxypropionic acid | 100 ± 11 | 910 ± 59 | 0.11 |
4-Chlorophenoxyacetic acid | 60 ± 5 | 1,700 ± 210 | 0.035 |
Phenoxyacetic acid | 30 ± 5 | 3,500 ± 400 | 0.009 |
3-Phenoxypropionic acid2-c | (No activation) | ||
2-Pheoxypropanol2-a | (No activation) |
↵2-a Smax is expressed as (v −v0)/v0 × 100 at the maximum stimulation. v and v0 represent the velocities in the absence and presence, respectively, of the activator.
↵2-b SC50 was determined from the activation phase of the activity vs. activator concentration curve.
↵2-c 3-Phenoxypropionic acid and 2-phenoxypropanol inhibited the activity at concentrations above 3 and 1 mM, respectively.