Table 3

Time course of available receptor fraction after clocinnamox administration in the squirrel monkey shock titration procedure

Clocinnamox dose	Pretreatment interval	Average q values^3-b	q values^3-a
Clocinnamox dose	Pretreatment interval	Average q values^3-b	Etorphine	Morphine	Buprenorphine
mg/kg
0.01	4 hr	0.67 ± 0.25		0.82 ± 0.43	0.46 ± 0.080^3-c
	3 days			0.65 ± 0.15	0.61 ± 0.41
	10 days			0.99 ± 0.061	1.61 ± 0.60
0.03	4 hr	0.038 ± 0.018	0.034 ± 0.0023	0.080 ± 0.049	0.00021 ± 0.000098
	3 days		0.70 ± 0.20^3-d	0.042 ± 0.029	0.16 ± 0.16
	10 days		1.3 ± 0.47	0.36 ± 0.27	0.50 ± 0.15
0.1	4 hr	0.00016 ± 0.00015	0.0000070 ± 0.0000065	0.00031 ± 0.00030
	3 days		0.29 ± 0.048	0.36 ± 0.22
	10 days		0.43 ± 0.053	0.62 ± 0.24

↵3-a Values were averaged across individual monkeys for a given drug (n = 2–3 determinations).
↵3-b Values were averaged across individual monkeys for all drugs (n = 5–9 determinations).
↵3-c Two monkeys were tested with 0.01 mg/kg clocinnamoxvs. buprenorphine.
↵3-d Individual q values returned significantly more quickly for etorphine (F_(2,6) = 5.7; P < .041).