Table 3

(−)DS121 effect on cumulated changes in NREM, REM and WAKE time (based on individual values of maximum wake-promoting duration)

Parameter3-aDose (−)DS121 in mg/kgANOVA
Vehicle0.51510
CT-5
Sample size (n)201181113
NREM
 max−16.2  ± 1.9−20.3  ± 3.3−42.9  ± 9.7−68.8  ± 5.93-150 −109.5  ± 7.63-150 F(4,62) = 15.23, P < .001
 t max 81.0  ± 7.992.7  ± 17.7150.0  ± 42.4180.0  ± 14.03-150 249.2  ± 20.23-150 F(4,62) = 6.04, P < .001
 24 h10.7  ± 3.711.5  ± 5.8−8.4  ± 16.6−1.1  ± 8.2−37.3  ± 10.43-150 F(4,62) = 6.45, P < .001
REM
 max−8.4  ± 0.9−8.1  ± 1.8−13.2  ± 2.8−32.3  ± 1.93-150 −40.5  ± 4.03-150 F(4,62) = 13.21, P < .001
 t max 144.0  ± 15.3130.9  ± 35.1187.5  ± 32.9370.9  ± 17.83-150 406.2  ± 23.73-150 F(4,62) = 9.62, P < .001
 24 h2.2  ± 2.7−6.3  ± 4.50.3  ± 3.1−10.9  ± 3.6−14.1  ± 5.83-150 F(4,62) = 3.26, P < .05
WAKE
 max22.3  ± 2.632.8  ± 7.452.3  ± 12.689.5  ± 7.73-150 135.8  ± 9.03-150 F(4,62) = 14.17, P < .001
 t max 81.0  ± 7.990.0  ± 13.4150.0  ± 42.4229.1  ± 19.53-150 267.7  ± 16.13-150 F(4,62) = 8.05, P < .001
 24 h−14.6  ± 5.7−5.0  ± 8.37.9  ± 16.612.1  ± 10.351.4  ± 14.03-150 F(4,62) = 6.89, P < .001
CT-18
Sample size (n)2013
NREM
 max−3.1  ± 1.2−33.2  ± 4.43-150 F(1,32) = 15.69, P < .001
 t max 30.0  ± 8.1193.8  ± 24.63-150 F(1,32) = 12.35, P < .005
 24 h6.1  ± 5.1−5.4  ± 7.4
REM
 max−1.9  ± 0.5−9.6  ± 1.93-150 F(1,32) = 6.20, P < .05
 t max 88.4  ± 17.6715.4  ± 55.03-150 F(1,32) = 20.02, P < .001
 24 h−1.1  ± 2.90.7  ± 3.7
WAKE
 max4.7  ± 1.335.1  ± 5.03-150 F(1,32) = 12.99, P < .005
 t max 164.0  ± 22.0184.6  ± 20.9
 24 h−5.6  ± 6.14.6  ± 9.7

  • ↵3-a Cumulated change parameters were defined as follows: max, maximum number of minutes of NREM, REM or WAKE accumulated post-treatment; tmax, number of minutes to reach maximum NREM, REM or WAKE accumulation; 24 h, number of minutes of NREM, REM or WAKE accumulated at 24 h post-treatment.

  • ↵3-150  P < .05 vs. vehicle (Dunnett’s contrasts).