The synergistic effect between DAMGO and DPDPE in naive mice when administered with i.t. at different ratios
| Ratios DAMGO/DPDPE | AD50 Values of Peptides (95% confidence limits) | |
|---|---|---|
| DAMGO | DPDPE | |
| nmol/mouse | ||
| 1:50 | 0.026 (0.01–0.04) | 1.3 (0.8–2.1) |
| 1:100 | 0.02 (0.01–0.035) | 2.0 (1.1–3.5) |
| 1:200 | 0.011 (0.006–0.022) | 2.2 (1.1–4.4) |
| 1:500 | 0.005 (0.003–0.008) | 2.3 (1.3–4.0) |