Determination of the apparent pA2 values of CTAP and NTI in antagonism of DAMGO and DPDPE in morphine-naive mice
| Antagonists | DAMGO | DPDPE | ||
|---|---|---|---|---|
| pA2 Values (95% confidence limits) | Slope ± S.E. | pA2 Values (95% confidence limits) | Slope ± S.E. | |
| CTAP | 11.13 (10.15–12.11) | −1.46 ± 0.31 | 11.07 (10.75–11.39) | −1.4 ± 0.1 |
| NTI | N.D.4-a | N.D.4-a | 9.04 (4.6–13.4) | −3.14 ± 0.93 |
↵4-a The pA2 value of NTI for DAMGO and its slope could not be determined because NTI, up to 20 nmol/mouse, was not able to increase the AD50 of DAMGO even 2-fold.