Table 1

Findings at cesarean section in dams treated with LGC-40863 during the organogenesis period

ParameterDose (mg/day/kg b.wt.)
050010002000
No. of pregnant animals22212325
Corpora lutea 15.23 ± 2.511-a 15.24 ± 2.28 15.30 ± 1.87 16.12 ± 2.79 
Implantations14.36 ± 3.55 14.29 ± 2.99 14.48 ± 1.97 14.92 ± 3.83 
 % to corpora lutea92.67 ± 17.1093.05 ± 10.5294.62 ± 6.99 91.12 ± 15.49
Fetal deaths
 Resorptions (total)24281524
  Early24281519
  Late0005
 Dead fetuses0002
Live fetuses
 Male/female139/153133/139170/148188/159
 Litter size13.27 ± 3.81 12.95 ± 3.31 13.83 ± 2.04 13.88 ± 4.16 
 % to implantation90.92 ± 11.8391.15 ± 14.2195.58 ± 6.36 93.01 ± 13.13
External anomalies
 Fetuses examined292272318347
 Fetuses affected (%)2  (0.7)1-b 6  (2.2)1-c 1  (0.3)1-d 1  (0.3)1-e
 Litters examined22212325
 Litters affected (%)2  (9.1)6  (29)1  (4.3)1  (4.0)
Body weight of live fetuses
 Male3.25 ± 0.333.14 ± 0.243.27 ± 0.193.40 ± 0.46
 Female3.08 ± 0.292.96 ± 0.253.06 ± 0.273.18 ± 0.43

  • ↵1-a Values are mean ± S.D.

  • ↵1-b Gastroschisis, vestigial tail.

  • ↵1-c Agnathia, anophthalmia, brachycephaly, club foot, edema, hematoma, kinky tail, lordosis, micrognathia, microcephaly, omphalocele.

  • ↵1-d Intraparietal hernia.

  • ↵1-e Hematoma.