Table 1

Effects in the rat hot box of a challenge dose of ABT-594 (0.3 μmol/kg i.p.) in rats receiving repeated treatment (5 days b.i.d.) with either saline or ABT-594 (0.3 μmol/kg i.p.) (n = 6/group)1-a

Repeated TreatmentPredrug Latency(s)Postdrug Latency(s)
Saline6.4  ± 2.012.8  ± 1.7*
ABT-5948.9  ± 0.612.5  ± 0.8*
  • 1-a Values are mean ± S.E.M.

  • * P < .05 vs. predrug latency.