Hemodynamic and angiographic measurements at baseline, and at 5, 10, 15, 30 and 60 min after a bolus i.v. injection of mibefradil (M), diltiazem (D) and normal saline (control, C)
| Baseline | 5 Min | 10 Min | 15 Min | 30 Min | 60 Min | ||
|---|---|---|---|---|---|---|---|
| HR (min−1) | C | 73 ± 5 | 72 ± 5 | 69 ± 51-a | 69 ± 41-a | 70 ± 5 | 68 ± 6 |
| M | 69 ± 5 | 83 ± 71-a | 80 ± 71-a | 77 ± 81-a | 72 ± 7 | 69 ± 4 | |
| D | 72 ± 5 | 83 ± 61-a | 82 ± 61-a | 80 ± 61-a | 75 ± 5 | 71 ± 4 | |
| mAoP (mmHg) | C | 104 ± 8 | 105 ± 9 | 105 ± 8 | 106 ± 8 | 105 ± 7 | 104 ± 7 |
| M | 104 ± 9 | 101 ± 9* | 100 ± 91-a | 100 ± 81-a | 101 ± 8 | 103 ± 8 | |
| D | 107 ± 8 | 102 ± 9* | 101 ± 81-a | 101 ± 81-a | 102 ± 8 | 97 ± 8 | |
| LVEDP (mmHg) | C | 15 ± 2 | 16 ± 2 | 15 ± 3 | 16 ± 3 | 16 ± 2 | 16 ± 2 |
| M | 17 ± 3 | 13 ± 2 | 12 ± 2 | 12 ± 2 | 13 ± 2 | 14 ± 2 | |
| D | 16 ± 2 | 15 ± 2 | 16 ± 2 | 16 ± 3 | 17 ± 2 | 14 ± 2 | |
| +dP/dt (mmHg/sec) | C | 1784 ± 162 | 1775 ± 198 | 1795 ± 215 | 1738 ± 168 | 1739 ± 153 | 1731 ± 135 |
| M | 1696 ± 152 | 1998 ± 2471-a | 1968 ± 2291-a | 2003 ± 2461-a | 2002 ± 192 | 1823 ± 211 | |
| D | 1835 ± 147 | 1858 ± 205 | 1905 ± 211 | 1951 ± 218 | 1925 ± 201 | 1814 ± 189 | |
| −dP/dt (mmHg/sec) | C | 1745 ± 158 | 1709 ± 188 | 1741 ± 226 | 1698 ± 184 | 1676 ± 163 | 1666 ± 141 |
| M | 1705 ± 143 | 1815 ± 195 | 1819 ± 189 | 1868 ± 168 | 1846 ± 142 | 1711 ± 147 | |
| D | 1884 ± 155 | 1833 ± 178 | 1864 ± 201 | 1860 ± 202 | 1868 ± 186 | 1730 ± 168 | |
| CO (liter/min) | C | 2.32 ± 0.26 | 2.30 ± 0.28 | 2.35 ± 0.30 | 2.32 ± 0.27 | 2.34 ± 0.30 | 2.18 ± 0.13 |
| M | 2.19 ± 0.35 | 3.33 ± 0.691-a | 3.19 ± 0.671-a | 3.35 ± 0.801-a | 2.95 ± 0.69 | 2.51 ± 0.46 | |
| D | 2.40 ± 0.18 | 2.83 ± 0.34 | 2.79 ± 0.321-a | 2.79 ± 0.32 | 2.58 ± 0.27 | 2.33 ± 0.24 | |
| SVR (dynes-sec-cm−5) | C | 3766 ± 332 | 3867 ± 361 | 3808 ± 374 | 3845 ± 334 | 3860 ± 366 | 4006 ± 313 |
| M | 4063 ± 281 | 2753 ± 2681-a | 2882 ± 3081-a | 2834 ± 3191-a | 3213 ± 339 | 3650 ± 393 | |
| D | 3607 ± 214 | 3024 ± 2331-a | 3039 ± 2241-a | 3045 ± 2161-a | 3286 ± 232 | 3541 ± 341 | |
| ESV (ml) | C | 67 ± 7 | 67 ± 7 | 66 ± 7 | |||
| M | 69 ± 7 | 57 ± 61-a | 61 ± 6 | ||||
| D | 66 ± 6 | 63 ± 7 | 67 ± 6 | ||||
| LV EF (%) | C | 29 ± 1 | 30 ± 1 | 29 ± 1 | |||
| M | 28 ± 1 | 41 ± 11-a | 36 ± 1 | ||||
| D | 30 ± 1 | 33 ± 3 | 30 ± 1 |
HR, Heart rate; mAoP, mean aortic pressure; LVEDP, left ventricular (LV) end-diastolic pressure; +dP/dt, LV peak rate of change of pressure during isovolumic contraction; −dP/dt, LV peak rate of change of pressure during isovolumic relaxation; CO, cardiac output; SVR, systemic vascular resistance; ESV, LV end-systolic volume; LV EF, LV ejection fraction.
↵1-a P < .05 relative to baseline.