ED50s for the visceromotor response (VMR) and ΔMAP to 60 mmHg CRD. All values are expressed in mg/kg. An ED50 for the ΔMAP was either estimated or was not obtained for all drugs tested.
| Drug | VMR | ΔMAP | ||
|---|---|---|---|---|
| Saline | HAc | Saline | HAc | |
| CI977 | 0.01 ± 0.004 | 0.01 ± 0.004 | 0.03 | |
| U69,593 | 0.5 ± 0.03 | 0.2 ± 0.08 | 0.07 ± 0.022-a | 0.13 ± 0.04 |
| U50,488 | 1.8 ± 0.4 | 0.9 ± 0.2 | 0.5 ± 0.12-a | 0.6 ± 0.4 |
| Morphine | 1.7 ± 0.3 | 2.2 ± 1.0 | 1.4 ± 0.4 | 1.4 ± 0.4 |
| EMD61,753 | 2.1 ± 0.04 | 2.8 ± 0.2 | 1.04 ± 0.96 | 0.96 ± 0.23 |
| ICI204,448 | 8.1 ± 1.4 | 8.3 ± 2.0 | 7.6 | |
↵2-a Significant difference between the VMR and ΔMAP ED50s within a treatment group.