Table 1

CRF changes in the DMN, VMN, AN and BNST in naı̈ve and tolerant rats 30 min after acute saline (s.c.) or naloxone (1 mg/kg s.c.) injection

GroupsDMNVMNANBNST
pg/mg protein
Naı̈ve + saline590  ± 361018  ± 996  ± 1453  ± 66
Naı̈ve + naloxone346  ± 691-a 722  ± 1061-b 8  ± 0.51-c 459  ± 55
Tolerant + saline413  ± 631-a 642  ± 461-b 4  ± 0.7589  ± 35
Tolerant + naloxone342  ± 47564  ± 724  ± 0.61-d 531  ± 44

Data are expressed as mean ± S.E.M. for five to six rats. The levels of significance were determined by one-way analysis of variance followed by a Newman-Keuls test.

  • ↵1-a P < .05 vs. naı̈ve + saline.

  • ↵1-b P < .01 vs. naı̈ve + saline.

  • ↵1-c P < .05 vs. naı̈ve + saline.

  • ↵1-d P < .01 vs. naı̈ve + naloxone.