Agonist | Condition | A502-a | 95% Confidence limits2-b | Dose ratio2-c |
---|---|---|---|---|
mg/kg | ||||
U50,488 | Base line | 0.53 | 0.33–0.86 | |
3 days | 4.3 | 1.1–172-c | 8.2 | |
7 days | 2.8 | 0.57–14 | 5.3 | |
10 days | 1.4 | 1.1–1.82-c | 2.7 | |
14 days | 1.3 | 1.1–1.62-c | 2.5 | |
17 days | 1.3 | 1.1–1.62-c | 2.5 | |
21 days | 1.4 | 1.2–1.52-c | 2.6 | |
28 days | 0.95 | 0.29–3.1 | 1.8 | |
35 days | 0.62 | 0.39–0.99 | 1.2 | |
EKC | Base line | 0.018 | 0.016–0.021 | |
3 days | 0.045 | 0.033–0.0622-c | 2.5 | |
7 days | 0.030 | 0.015–0.059 | 1.6 | |
10 days | 0.039 | 0.031–0.0492-c | 2.1 | |
14 days | 0.018 | 0.017–0.019 | 1.0 | |
17 days | 0.015 | 0.010–0.022 | 0.8 | |
21 days | 0.020 | 0.010–0.040 | 1.1 | |
CI-977 | Base line | 0.0062 | 0.0030–0.013 | |
3 days | 0.0084 | 0.0014–0.049 | 1.4 | |
7 days | 0.0059 | 0.0024–0.014 | 1.0 | |
14 days | 0.0057 | 0.0026–0.013 | 0.9 | |
Alfentanil | Base line | 0.045 | 0.028–0.072 | |
1 day | 0.067 | 0.015–0.31 | 1.5 | |
10 days | 0.048 | 0.042–0.055 | 1.1 |