Liver | Activities of CYP450s | V of DHPBI | ||||
---|---|---|---|---|---|---|
CYP3A | CYP2D6 | CYP1A2 | CYP2C19 | CYP2E1 | ||
pmol/min/mg P | pmol/min/mg P | |||||
2 | 475 | 488 | 2400 | 7.1 | 906 | 163.9 |
3 | 270 | 0 | 750 | 0.9 | ND | 30.9 |
4 | 225 | 159 | 505 | 14.7 | 212 | 68.8 |
5 | 110 | 0 | 505 | 3.5 | 177 | 31.0 |
6 | 140 | 129 | 400 | 3.1 | 1118 | 15.8 |
7 | 350 | 118 | 450 | 2.3 | 224 | 77.3 |
8 | 185 | 229 | 1505 | 6.4 | 671 | 67.5 |
9 | 455 | 247 | 1400 | 23.6 | 471 | 74.7 |
16 | ND | ND | ND | 4.4 | ND | 141.0 |
Correlation (rs) | 0.79 | 0.61 | 0.46 | 0.37 | 0 | |
P value | 0.028* | 0.12 | 0.27 | 0.33 | 1 |
Data are averages of duplicate measurements
* Statistically significant (activity of CYP3A vs. V of DHPBI); ND, not determined.