ED50 values (mg/kg) for kappa opioid agonists after either 4-hr or 1-day pretreatment with C-CAM (0.1 mg/kg)
| Agonists | ED503-a (95% CL) | DR | |
|---|---|---|---|
| Base line | + C-CAM 0.1 mg/kg | ||
| EKC | 0.019 (0.015–0.023) | 0.052 (0.045–0.061)* | 2.8 |
| U69,593 | 0.045 (0.027–0.074) | 0.042 (0.023 0.076) | 0.9 |
| U50,488 | 0.56 (0.46–0.67) | 0.65 (0.50–0.84) | 1.2 |
| Bremazocine | 0.0089 (0.0050–0.016) | 0.0086 (0.0053–0.014) | 1.0 |
| Enadoline | 0.0057 (0.0035–0.0090) | 0.0055 (0.0035–0.0088) | 1.0 |
↵3-a ED50 values were the mean of individual ED50 values (n = 4–7). For other details, see “Results.”
* Indicates that the ED50 value is significantly different from the base line, P < .05.