Physiological and subjective withdrawal symptoms as a function of LAAM maintenance dose and time since last dose1-a
| 25 mg (n = 8) | 75 mg (n = 8) | LAAM group F(1,14) | Time F(3,42) | LAAM Group × Time F(3,42) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hours Since LAAM Dosing | |||||||||||
| 24 | 48 | 72 | 96 | 24 | 48 | 72 | 96 | ||||
| Physiological measures | |||||||||||
| Skin temperature (°F) | 88.0 | 84.3 | 85.3 | 78.3 | 88.7 | 84.8 | 85.3 | 83.6 | 0.71 | 5.69** | 0.94 |
| Respiration (breaths/min) | 18.0 | 19.5 | 19.3 | 23.0 | 14.8 | 16.0 | 17.0 | 18.5 | 5.07* | 4.57** | 0.29 |
| Systolic blood pressure (mm Hg) | 109.6 | 106.3 | 105.2 | 113.4 | 100.9 | 106.0 | 105.0 | 101.7 | 1.92 | 0.52 | 3.43* |
| Subjective measures1-b | |||||||||||
| Painful joints | 0.1 | 0.0 | 0.4 | 0.8 | 0.4 | 0.4 | 0.6 | 0.8 | 0.37 | 3.47* | 0.33 |
| Yawning | 0.3 | 0.1 | 1.0 | 0.6 | 0.3 | 0.5 | 0.6 | 0.5 | 0.01 | 2.98* | 1.10 |
| Watery eyes | 0.3 | 0.4 | 0.9 | 0.8 | 0.1 | 0.1 | 0.3 | 0.3 | 2.80 | 3.14* | 1.21 |
| Runny nose | 0.4 | 0.3 | 0.4 | 0.8 | 0.0 | 0.0 | 0.3 | 0.9 | 0.57 | 4.21* | 0.49 |
| Chills/gooseflesh | 0.1 | 0.0 | 0.4 | 1.6 | 0.0 | 0.0 | 0.4 | 0.1 | 4.24# | 7.33** | 6.13** |
| Hot/cold flashes | 0.1 | 0.0 | 0.5 | 0.9 | 0.0 | 0.1 | 0.4 | 0.1 | 1.35 | 3.98* | 2.49# |
| Depressed | 0.0 | 0.1 | 0.5 | 0.9 | 0.5 | 0.4 | 0.5 | 0.1 | 0.00 | 1.33 | 4.67* |
↵1-a Mean values for measures for which significant main or interaction effects were observed are shown for each interval (see also fig. 1 for other measures). Data were derived from baseline measures collected before the injection of drug during each session. #P < .10; *P < .05; **P < .01.
↵1-b Scores can range from 0 to 4.