HPLC analyses of tissue extracts and urine
| Sample | Time after peptide injection | Intact peptide found | ||
|---|---|---|---|---|
| BIM-23014 | BIM-23190 | BIM-23197 | ||
| % | ||||
| Pooled urine | 0–60 min | 21 | N.D. | N.D. |
| Pooled urine | 0–8 hr | 0 | 36 | 46 |
| Kidney | 60 min | 16 | 65 | 59 |
| Small intestine | 60 min | 30 | N.D. | N.D. |
| Liver | 60 min | 36 | 38 | 34 |
| Stomach | 60 min | 15 | 59 | 86 |
| Pancreas | 60 min | 33 | 60 | 71 |
| Heart | 60 min | N.D. | 31 | 26 |
| Adrenals | 60 min | N.D. | <5 | 9 |
| Lung | 60 min | 71 | N.D. | N.D. |
N.D. = not determined.