Zidovudine clearances and volumes of distribution
| Parameter | Infusion Study | Bolus Study | ||
|---|---|---|---|---|
| Nonparametric model* | Three-compartment model | Nonparametric model+ | Five-compartment model | |
| CLdf | 1.79 ± 0.24 | 1.65 ± 0.16 | 2.21 ± 0.20 | 2.03 ± 0.25 |
| CLfd | 2.46 ± 0.50 | 2.36 ± 0.27‡ | 2.40 ± 0.09‡ | 2.19 ± 0.22‡ |
| CLdf (norm) | 0.37 ± 0.06 | 0.29 ± 0.02 | 0.42 ± 0.01 | 0.38 ± 0.02 |
| CLfd (norm) | 0.39 ± 0.06§ | 0.35 ± 0.05§ | 0.42 ± 0.03§ | 0.41 ± 0.03§ |
| CLdo | 32.65 ± 7.34 | 32.21 ± 6.62 | 30.40 ± 6.50 | 28.31 ± 3.24 |
| CLfo | 0.00 ± 0.02 | 0.09 ± 0.02 | 0.26 ± 0.16 | 0.07 ± 0.07 |
| CLfa | 0.09 ± 0.04 | 0.04 ± 0.01 | ||
| CLaf | 0.04 ± 0.05 | 0.03 ± 0.02 | ||
| CLda | 0.07 ± 0.01 | 0.04 ± 0.03 | ||
| CLad | 0.03 ± 0.02 | 0.02 ± 0.01 | ||
| CLao | 0.03 ± 0.01 | |||
| V dc | 314.40 ± 17.61 | 340.80 ± 163.07 | ||
| V fc | 63.59 ± 2.77 | 26.80 ± 16.04 | ||
| V a | 10.00 ± 5.81 | 14.47 ± 8.09 | ||
Abbreviations and symbols: S.D., standard deviation; * calculated with steady-state concentrations and infusion rates;+ calculated with AUCs and bolus doses; CL, clearance,ml/min/kg; V, volume of distribution,ml/kg; d, dam; f, fetus; a, amniotic fluid; o, irreversible clearance; norm, normalized to the corresponding antipyrine clearance; c, central compartment.
‡ Not significantly different from corresponding CLdf (P > .05).
§ Not significantly different from corresponding CLdf(norm) (P > .05).