Pharmacological properties of hGluR3i determined by whole-cell recordings in HEK69-8 cells
| Compound | EC50values | nH | n | Efficacy |
|---|---|---|---|---|
| μM | ||||
| Glutamate | 163 (126, 211) | 1.7 ± 0.2 | 4 | 100 |
| Kainate | 45.5 (37.4, 55.4) | 1.3 ± 0.1 | 5 | 22 ± 4 |
| AMPA | 62.2 (44.2, 87.7) | 1.2 ± 0.4 | 4 | 103 ± 6 |
EC50 values were determined at hGluR3i by electrophysiological whole-cell recordings. Data are expressed as the geometric mean (lower, upper S.D.), and the Hill slope,nH, expressed as the mean ± S.D.