Table 1

Displacement of [³H]flunitrazepam binding to the GABA_A receptor complex

Treatment	Concentration	n	Percentage of control	S.E.M.
			%
Control		22	100.0	7.5
Flumazenil	30 μM	11	8.2^1-a	1.0
Triazolam	1 nM	10	83.5	3.5
	3 nM	10	71.4^1-a	3.1
	9 nM	10	39.6^1-a	2.3
Ketoconazole	1 μM	12	58.2^1-a	1.9
	3 μM	6	31.4^1-a	2.0
	9 μM	6	10.7^1-a	3.5
Itraconazole	1 μM	6	68.1^1-a	6.7
	3 μM	6	86.9	8.1
	9 μM	6	65.7^1-a	11.4
Buspirone	1 μM	6	77.5	9.8
	3 μM	6	94.7	7.4
	9 μM	6	88.8	10.1
Dizocilpine	1 μM	6	87.4	9.1
	3 μM	6	87.7	7.9
	9 μM	6	86.8	8.8
Paroxetine	1 μM	6	70.4^1-a	9.5
	3 μM	6	69.3^1-a	5.2
	9 μM	6	64.4^1-a	9.6

Data represent mean displacement of specific [³H]flunitrazepam binding to mouse brain cortical synaptosomes expressed as a percentage of control binding within each assay. n represents the number of individual assays performed, each in triplicate. Control values were calculated as follows: total specific binding values (pmol/mg) from all assays were averaged and total specific binding values (pmol/mg) from each individual assay were expressed as a percentage of the total mean.

↵1-a P < .05, significant differences from control as determined by ANOVA and Dunnett’s post hoc test.