Hemodynamic effects of myocardial stunning in dogs receiving vehicle1-a
| Base line | Vehicle | Fifth occlusion | Reperfusion (min) | |||||
|---|---|---|---|---|---|---|---|---|
| 15 | 30 | 60 | 120 | 180 | ||||
| HR (bpm) | 134 ± 9 | 137 ± 10 | 141 ± 10 | 141 ± 10 | 142 ± 9 | 145 ± 9 | 146 ± 9* | 148 ± 7* |
| MBP (mm Hg) | 106 ± 4 | 104 ± 5 | 95 ± 4 | 105 ± 6 | 105 ± 6 | 104 ± 6 | 103 ± 7 | 99 ± 8 |
| LVSP (mm Hg) | 115 ± 4 | 114 ± 5 | 105 ± 6 | 113 ± 7 | 113 ± 6 | 113 ± 6 | 112 ± 7 | 109 ± 9 |
| LVEDP (mm Hg) | 9 ± 2 | 7 ± 3 | 11 ± 3* | 9 ± 3 | 8 ± 3 | 8 ± 3 | 7 ± 3 | 6 ± 3 |
| +dP/dt max (mm Hg · s−1) | 1676 ± 126 | 1546 ± 135 | 1412 ± 93 | 1345 ± 43* | 1350 ± 57* | 1368 ± 57 | 1382 ± 101 | 1441 ± 119 |
| CO (l · min−1) | 2.4 ± 0.4 | 2.1 ± 0.4 | 1.7 ± 0.3* | 1.7 ± 0.3* | 1.7 ± 0.3* | 1.6 ± 0.3* | 1.6 ± 0.3* | 1.5 ± 0.3* |
| SVR (dyn · s · cm−5) | 4420 ± 940 | 5470 ± 1490 | 5810 ± 1330 | 6380 ± 1480 | 6480 ± 1650 | 7450 ± 2260 | 8390 ± 3030* | 8380 ± 3110* |
| SV (ml) | 18 ± 3 | 16 ± 3 | 12 ± 3* | 12 ± 2* | 12 ± 2* | 11 ± 2* | 12 ± 3* | 11 ± 2* |
| PWI (ml · min−1 · g−1) | 10.9 ± 0.6 | 10.5 ± 0.7 | 9.4 ± 0.7 | 10.2 ± 0.7 | 10.3 ± 0.5 | 10.2 ± 0.4 | 10.2 ± 0.4 | 9.9 ± 0.5 |
| pH | 7.38 ± 0.03 | 7.36 ± 0.02 | 7.38 ± 0.03 | – | 7.33 ± 0.02 | 7.34 ± 0.02 | 7.33 ± 0.03 | 7.33 ± 0.02 |
| PO2 (mm Hg) | 351 ± 36 | 289 ± 32 | 366 ± 28 | – | 376 ± 32 | 404 ± 46 | 408 ± 32 | 371 ± 51 |
| PCO2 (mm Hg) | 32 ± 2 | 31 ± 3 | 30 ± 2 | – | 30 ± 1 | 33 ± 1 | 32 ± 1 | 31 ± 1 |
| Hb (g · dl−1) | 11.5 ± 0.5 | 12.3 ± 0.5 | 12.8 ± 0.3 | – | 13.0 ± 0.4 | 13.3 ± 0.3 | 12.7 ± 0.6 | 13.2 ± 0.8 |
| P50 (mm Hg) | 31 ± 1 | 32 ± 1 | 32 ± 0 | – | 32 ± 0 | 33 ± 1 | 34 ± 1 | 33 ± 1 |
| n 50 | 2.63 ± 0.05 | 2.54 ± 0.11 | 2.68 ± 0.04 | – | 2.70 ± 0.08 | 2.60 ± 0.05 | 2.53 ± 0.07 | 2.58 ± 0.08 |
↵1-a Data are mean ± S.E.M.; n = 7. Abbreviations: HR, heart rate; MBP, mean aortic blood pressure; LVSP and LVEDP, left ventricular systolic and end-diastolic pressure, respectively; CO, cardiac output; SV, stroke volume; SVR, systemic vascular resistance; PWI, pressure-work index; Hb, hemoglobin concentration; P50, partial pressure of oxygen at 50% hemoglobin saturation; n50, Hill coefficient at 50% hemoglobin saturation.
* Significantly (P < .05) different from vehicle.