Table 3

Strychnine-induced changes in the kinetics of type IA currents

[Strychnine] (μM)Rise Time (% of Control)Decay-Time Constant (τ) (% of Control)
0.3107  ± 11 (6)3-a 126  ± 5 (6)
1132  ± 18 (4)188  ± 12 (4)
3168  ± 26 (4)388  ± 138 (4)
  • 3-a Mean ± S.E.M. (number of neurons). Under control conditions, the rise time of ACh (0.3 mM)-evoked type IA currents ranged from 15 to 27 msec (n = 14). The decay phase of currents recorded from 11 neurons was best fitted by a single-exponential function and the decay-time constant of these currents ranged from 15.2 to 52.1 msec. The decay phase of the currents recorded from three neurons was fitted by a double-exponential function, and the τf of these currents, which varied from 14.6 to 22.7 msec, was used in averaging the results.