EC50 values for ET-1 and S6c, in the absence and presence of 100 μM L-NAME, in PRAs from sham-operated rabbits and rabbits with LVD
| Agonist or Agonist + L-NAME | Sham-Operated Rabbits | LVD Rabbits | ||
|---|---|---|---|---|
| pEC50 | n/n | pEC50 | n/n | |
| ET-1 | 7.9 ± 0.3 | 8 /6 | 7.9 ± 0.2 | 12 /7 |
| ET-1 + L-NAME | 8.3 ± 0.2 | 9 /7 | 8.7 ± 0.2* | 7 /6 |
| S6c | 9.0 ± 0.2 | 10 /9 | 8.6 ± 0.2 | 11 /7 |
| S6c + L-NAME | 9.2 ± 0.3 | 5 /5 | 10.4 ± 0.3*** | 8 /6 |
Statistical comparisons were made by Student’s unpairedt test; compared with response in sham-operated group, * P < 0.05, *** P < 0.001.
Values are mean ± S.E.M.
n/n: number of ring preparations/number of animals.