Nicotinic antagonists injected into cerebral aqueduct block nicotine-stimulated NE release in AMYG and HP: approximate IC50values and efficacies
| Antagonists | AMYG | HP | ||
|---|---|---|---|---|
| Approximate IC50 | Maximal Inhibition | Approximate IC50 | Maximal Inhibition | |
| nmol | % | nmol | % | |
| Mec | 6 | 80 | 6 | 87 |
| DHβE | 8 | 62 | 15 | 63 |
| MLA | 5 | 60 | 5 | 66 |