Dose of Drug | Neurons/μm2(×10−4)2-a | |
---|---|---|
Ventral | Middle | |
325–375 mg/kg pilocarpine | ||
0 mg/kg U50488h | 2.6 ± 0.5 (15) | 2.7 ± 0.5 (15)2-b |
10 mg/kg U50488h | 2.8 ± 0.1 (8) | 3.8 ± 0.4 (8)2-c |
20 mg/kg U50488h | 4.3 ± 0.4 (10)2-d | 4.2 ± 0.5 (10)2-e |
20 mg/kg U50488h + nBNI | 5.1 ± 0.6 (6)c,d | 4.1 ± 0.5 (6) |
275 mg/kg pilocarpine | ||
0 mg/kg nBNI | 3.9 ± 0.5 (15) | 4.5 ± 0.4 (15) |
10 mg/kg nBNI | 3.9 ± 0.6 (9) | 3.2 ± 0.5 (9)b,f |
0 mg/kg pilocarpine | 3.4 ± 0.4 (16) | 5.2 ± 0.3 (16) |
↵2-a Data are means ± S.E.M. with the number of rats shown in parentheses
↵2-b Significant difference from 0 mg/kg pilocarpine (one-way ANOVA), LSD post hoc comparison, P < .01).
↵2-c Significant difference from 0 mg/kg pilocarpine (one-way ANOVA, LSD post hoc comparison, P < .05).
↵2-d Significant difference from 0 mg/kg U50488h (one-way ANOVA, LSD post hoc comparison, P < .01).
↵2-e Significant difference from 0 mg/kg U50488h (one-way ANOVA, LSD post hoc comparison, P < .05).
2-f Significant difference from 0 mg/kg nBNI (one-way ANOVA, LSDpost hoc comparison, P < .05).