Table 2

Hilar cell loss

Dose of DrugNeurons/μm2(×10−4)2-a
VentralMiddle
325–375 mg/kg pilocarpine
 0 mg/kg U50488h2.6  ± 0.5  (15) 2.7  ± 0.5  (15)2-b
 10 mg/kg U50488h2.8  ± 0.1  (8)  3.8  ± 0.4  (8)2-c 
 20 mg/kg U50488h4.3  ± 0.4   (10)2-d 4.2  ± 0.5  (10)2-e
 20 mg/kg U50488h +  nBNI5.1  ± 0.6  (6)c,d 4.1  ± 0.5  (6)  
275 mg/kg pilocarpine
 0 mg/kg nBNI3.9  ± 0.5  (15)4.5  ± 0.4 (15) 
 10 mg/kg nBNI3.9  ± 0.6  (9) 3.2  ± 0.5  (9)b,f
 0 mg/kg pilocarpine3.4  ± 0.4  (16)5.2  ± 0.3  (16) 

  • ↵2-a Data are means ± S.E.M. with the number of rats shown in parentheses

  • ↵2-b Significant difference from 0 mg/kg pilocarpine (one-way ANOVA), LSD post hoc comparison, P < .01).

  • ↵2-c Significant difference from 0 mg/kg pilocarpine (one-way ANOVA, LSD post hoc comparison, P < .05).

  • ↵2-d Significant difference from 0 mg/kg U50488h (one-way ANOVA, LSD post hoc comparison, P < .01).

  • ↵2-e Significant difference from 0 mg/kg U50488h (one-way ANOVA, LSD post hoc comparison, P < .05).

  • 2-f Significant difference from 0 mg/kg nBNI (one-way ANOVA, LSDpost hoc comparison, P < .05).