Ligand | MLA |
---|---|
AD50(nnoml/mouse)3-a | |
(−)-Nicotine | 16 (10–23) |
(+)-Nicotine | 5 (1.5–8) |
(−)-Epibatidine | 7 (2–17) |
(+)-Epibatidine | 5 (2–14) |
6-Chloronicotine | 34 (24–43) |
nor-Nicotine | 25 (17–28) |
(+)-BN | 25 (16–40) |
(±)-Iso-nicotine | 6 (4–15) |
N-MCC | 46 (24–89) |
ABT-418 | 15 (8–19) |
N-MNP | 17 (14–23) |
AMP-ME | 2% blockade @ 90 |
AMP-MP | 2% blockade @ 90 |
DMPP | 20% blockade @ 90 |
Lobeline | 5% blockade @ 90 |
↵3-a Mice were pretreated i.t. with different doses of MLA 5 min before nicotine agonists and mice were tested 5 min after in the tail-flick test. Results are expressed as AD50 values ± CL.