Table 3

Effect of clofibrate pretreatment on the distribution of ibuprofen into various tissues [data are given as ibuprofen/tissue (μg/g; mean ± S.E.M.)]

TissueConcentration of Ibuprofen (μg ibuprofen/g tissue)P
Control groupClofibrate Group
Fat5.70  ± 1.198.42  ± 1.18.0004
Lung5.23  ± 2.188.62  ± 3.18.03
Brain0.89  ± 0.421.93  ± 1.16.03
Kidney17.32  ± 11.5024.95  ± 10.51.19
Liver13.32  ± 8.5034.71  ± 17.73.008