Table 1

Mean (±S.E.M.) pharmacokinetic parameters of the enantiomers of ibuprofen in clofibrate treated (n = 8) and control (n = 7) rats

ParameterR-IbuprofenP
ControlTreated
CL (ml/min)13.0  (± 1.4)29.4  (± 4.0).003
VSS (liter/kg)1.03  (± 0.30)4.42  (± 1.12).017
t1/2(min)38.5  (± 8.1)89.3  (± 29.9).148
CLRI(ml/min)10.0  (± 1.2)23.2  (± 3.2).003
Parameter 13C-S-IbuprofenP
Control Treated
CL (ml/min)4.2  (± 0.3)4.5  (± 0.7).65
VSS(liter/kg)1.10  (± 0.21)1.04  (± 0.13).82
t1/2 (min)107.6  (± 23.0)101.0  (± 16.7).81