Combined effect model parameters
| Effect | Potency Ratio (−)/(+) | Base line | Emax | EC50 (−) | MSC |
|---|---|---|---|---|---|
| Q h | 2 | 0.093 | 0.109 | 0.14 | 4.19 |
| (0.077–0.109) | (0.093–0.125) | (0.06–0.22) | |||
| LV dP/dt max | 4 | 2659 | 1445 | 0.64 | 5.05 |
| (2541–2777) | (1084–1805) | (0.22–1.06) | |||
| PR interval | 10 | 9.59 | 5.31 | 0.045 | 5.58 |
| (6.80–12.38) | (4.39–6.22) | (0.003–0.090) |
The parameters of the best dynamic models for changes in myocardial blood flow (Qh), the maximum rate of rise of left ventricular pressure (LV dP/dtmax) and A-V conduction (PR interval) relative to arterial (Qh) and coronary sinus blood (LV dP/dtmax and PR interval) for both the (+)- and (−)-enantiomers based on the potency ratios shown. An example of the equations of the dynamic models is shown in the text. The data are shown as the mean and upper and lower 95% confidence limits.