Lung kinetic models
| Vlung(l) | ERlung | PS (l/min) | Vdeep(l) | R2 | MSC | |
|---|---|---|---|---|---|---|
| (+)-Enantiomer | ||||||
| Flow | 4.78 | 0.962 | 2.82 | |||
| (3.91–5.65) | ||||||
| Flow + ER | 3.45 | 0.22* | 0.995 | 4.93 | ||
| (3.13–3.77) | (0.20–0.25) | |||||
| Membrane | 4.20* | 2.14 | 24.3* | 0.997 | 5.27 | |
| (3.83–4.58) | (1.84–2.44) | (13.9–36.6) | ||||
| (−)-Enantiomer | ||||||
| Flow | 5.27 | 0.951 | 2.60 | |||
| (4.24–6.32) | ||||||
| Flow + ER | 3.57 | 0.26 | 0.996 | 5.16 | ||
| (3.28–3.88) | (0.23–0.28) | |||||
| Membrane | 4.78 | 2.29 | 60.79 | 0.997 | 5.29 | |
| (4.36–5.13) | (2.02–2.56) | (21.5–100) |
The parameters of the flow-limited (flow), flow-limited with extraction (flow + ER) and membrane-limited (membrane) lung kinetic models for each enantiomer. Goodness of fit is given by theR2 value and the MSC (see the text). A higher MSC indicates a better fit. The data are shown as the mean and upper and lower 95% confidence limits. An asterisk indicates that the value for the (+)-enantiomer was statistically different from that for the (−)-enantiomer by comparison of the mean with the 95% confidence limits.