Table 4

Effect of therapeutic l-NIL treatment on adjuvant-induced arthritis in the rat.

Treatment	Plasma NOx	Change in Volume		RAD Score		Change in Body Weight	Thymus Weight	Spleen Weight
Treatment	Plasma NOx	Primary paw	Secondary paw	Primary paw	Secondary paw	Change in Body Weight	Thymus Weight	Spleen Weight
		μM	μl			g	g	g
Naive	26 ± 7	57 ± 59	58 ± 58	0.0 ± 0.0	0.0 ± 0.0	49.4 ± 11.2	496 ± 38	428 ± 32
Vehicle	76 ± 10	1844 ± 412	1280 ± 495	13.2 ± 3.3	9.6 ± 4.5	13.9 ± 4.5	275 ± 66	768 ± 111
l-NIL (60 mg/kg/day)	26 ± 6^**	2395 ± 547	1142 ± 525	14.1 ± 4.2	10.5 ± 5.3	8.2 ± 7.3	216 ± 78	614 ± 78

Vehicle or compounds were administered twice daily beginning 14 days after injection of adjuvant. Paw volumes and body weights are expressed as the change from day 0. Plasma NOx levels were determined 16 hr after the last administration of compounds, after sacrifice on day 21.

* P < .05, ** P < .01 compared with the vehicle control group.