Effect of AngII on release of CGRP-LI (fmol/ml) induced by PNS in perfused mesenteric vascular beds with active tone in SHRs and WKYs4-a
| SHR | WKY | |
|---|---|---|
| Control | ||
| PNS1 (control) | 0.3428 ± 0.0878 (6)** | 0.8145 ± 0.1014 (5) |
| PNS2(control) | 0.3490 ± 0.0746 | 0.8295 ± 0.6965 |
| S2/S1 ratio | 1.0947 ± 0.1366 | 1.0356 ± 0.0991 |
| AngI | ||
| PNS1 (control) | 0.1878 ± 0.0505 (4)** | 0.9398 ± 0.1004 (4) |
| PNS2(AngI) | 0.0865 ± 0.0249 | 1.0080 ± 0.3090 |
| S2/S1 ratio | 0.6526 ± 0.2944 | 1.1415 ± 0.3403 |
| AngII | ||
| PNS1 (control) | 0.3014 ± 0.0497 (5) | 0.7782 ± 0.3142 (5) |
| PNS2(AngII) | 0.0943 ± 0.0278 | 0.7024 ± 0.2719 |
| S2/S1 ratio | 0.4162 ± 0.0938** ‡ | 0.9317 ± 0.0572 |
↵4-a PNS1, the first PNS without the agonist; PNS2, the second PNS during perfusion of the agonist. ** P < .01, compared with WKYs (Student’s t test); ‡ P < .01, compared with control (Tukey’s test). The number of animals is in parentheses.