Focal seizure threshold before and after chronic treatment with levetiracetam during kindling development (see legend to table 1 for details)
| Group | Prekindling ADT (μA) | Postkindling ADT (μA) |
|---|---|---|
| I | 248 ± 41 | 120 ± 32 |
| II | 248 ± 31 | 76 ± 16 |
| III | 270 ± 47 | 80 ± 12 |
| IV | 249 ± 43 | 88 ± 19 |
The table shows the initial (pre-kindling) afterdischarge threshold (ADT) determined 1 day before onset of treatment and the ADT determined in fully kindled rats 1 week after the 10th stage 5 seizure. In all groups, postkindling ADTs were significantly lower than pre-kindling ADTs (P at least <.05). There was no significant difference between groups in either prekindling or postkindling ADTs. All data are shown as means ± S.E.