Summary of pharmacokinetic parameters for lisofylline2-a
| Lisofylline Dose | Cmax | tmax | AUC0–∞ | Eliminationt½ | |
|---|---|---|---|---|---|
| mg/kg | ng/ml | hr | ng · hr/ml | hr | |
| 1 | i.v. | 2075 ± 562.9 | 0.17 ± 0 | 950 ± 179.5 | 0.75 ± 0.107 |
| 2 | i.v. | 3829 ± 1513.0 | 0.16 ± 0.026 | 1838 ± 357.9 | 0.74 ± 0.087 |
| 3 | i.v. | 5698 ± 1626.5 | 0.15 ± 0.041 | 2756 ± 644.2 | 0.77 ± 0.123 |
| 6 | p.o. | 226 ± 99.1 | 0.53 ± 0.256 | 343 ± 102.0 | 0.90 ± 0.224 |
↵2-a Values are stated as means ± S.D.Cmax, maximum plasma concentration;tmax, time to maximum concentration; AUC0–∞, area under the plasma concentration-time curve extrapolated to infinity; t½, elimination half-life.