Potencies of 5-HT1A ligands to substitute in rats and pigeons trained to discriminate 8-OH-DPAT from saline
| Compound | Dose range | Drug-Appropriate Selection | Rate of Responding | |||||
|---|---|---|---|---|---|---|---|---|
| n | ED50 | 95% C.L. | max | ED50 | 95% C.L. | max (mean ± S.E.M.) | ||
| mg/kg | mg/kg | % | mg/kg | (%) | ||||
| Rat | ||||||||
| BMY-7378 | 0.04–2.5 | 9 | 0.94 | 0.32–2.7 | 80 | 0.57 | 0.20–1.7 | 3.8 ± 1.4 |
| Idazoxan | 2.5–10 | 7 | 6.7 | 2.5–18 | 67 | 3.2 | 1.2–8.3 | 36 ± 15 |
| LEK88043-a | 0.010–0.16 | 9 | 0.089 | 0.035–0.23 | 80 | 0.037 | 0.015–0.090 | 29 ± 13 |
| Yohimbine | 0.63–10 | 7 | 3.4 | 0.91–13 | 75 | 1.8 | 0.70–4.7 | 0.9 ± 0.4 |
| Lisuride | 0.0025–0.04 | 7 | >0.04 | 60 | 0.0058 | 0.0027–0.012 | 21 ± 6.5 | |
| Eltoprazine | 0.63–2.5 | 7 | >2.5 | 57 | 0.76 | 0.46–1.2 | 20 ± 8.4 | |
| Pigeon | ||||||||
| BMY-7378 | 0.16–10 | 7 | >10 | 29 | 1.7 | 0.59–4.6 | 58 ± 12 | |
| Idazoxan | 0.63–40 | 7 | >40 | 29 | 7.3 | 2.9–19 | 13 ± 13 | |
| LEK8804 | 0.01–0.16 | 7 | >0.16 | 29 | 0.048 | 0.021–0.11 | 18 ± 18 | |
| Yohimbine | 0.16–2.5 | 7 | >2.5 | 33 | 0.26 | 0.11–0.61 | 0 ± 0 | |
| Lisuride | 0.0025–0.04 | 7 | 0.007 | 0.0028–0.019 | 100 | 0.020 | 0.0059–0.065 | 61 ± 17 |
| Eltoprazine | 0.63–10 | 7 | 1.2 | 0.58–2.5 | 100 | 3.5 | 1.3–9.0 | 17 ± 17 |
↵3-a Drug-lever selection results have been reported elsewhere (Kleven et al., 1997).