Table 4

Antagonism of the BMY 14802 and 8-OH-DPAT stimulus effects by NAN 190 in BMY 14802-trained pigeons

CompoundED50Potency ratio
mg/kg (95% CL) ratio 95% CL
BMY 14802
 Control1.1  (0.68–1.8)
 +0.32 mg/kg NAN 1904.94-b  (2.6–9.1)0.23  (0.10–0.53)
 +3.2 mg/kg NAN 190Not applicable4-a Not applicable4-a
8-OH-DPAT
 Control0.55  (0.25–1.2)
 +0.32 mg/kg NAN 1901.44-b  (0.59–3.4)0.35  (0.098–1.4)
 +3.2 mg/kg NAN 1901.64-b  (1.0–2.7)0.29  (0.076–2.0)

  • ↵4-a Less than 50% of all responses were directed to the BMY 14802-appropriate keys at any dose tested.

  • ↵4-b Significantly different from control value (P < .05).