Pharmacokinetic parameters after i.t. administration of IgG and IgM mAbs to rats and monkeys
| Rats (RNU/NU) | Rhesus monkeys | |||
|---|---|---|---|---|
| IgG mAb 3F8 (n = 5) | IgM mAb 3A7 (n = 4) | Acetazolamide furosemide treatment | IgG mAb3F8 (n = 4) | |
| IgG mAb 3F8 (n = 5) | ||||
| CSF (5 to 360 min) | ||||
| t½α (min) | 13.8 (5.8) | 15 (2.6) | 19.7 (7.9) | |
| t½β (min) | 58.5 (16.8) | 137.5 (108) | 86.41-a (26.7) | 53.8 (12.9) |
| AUC (μg*min/ml) | 18100 (8721) | 316711-a (9766) | 397351-a (14910) | 13625 (2248) |
| Clearance (ml/min) | 0.01 (0.0058) | 0.00411-a (0.0016) | 0.00431-a (0.0019) | 0.15 (0.030) |
| Volume of distribution (ml) | 0.23 (0.036) | 0.131-a (0.03) | 0.19 (0.09) | 12 (5) |
| Serum (5 to 360 min) | ||||
| Mean concentration (μg/ml) | 1.04 (0.98) | 0.37 (0.17) | 0.34 (0.19) | |
| AUC (μg* min/ml) | 378 (359) | 133 (63) | 123 (67) | |
| AUC CSF/AUC blood (for each animal) | 93 (75) | 2801-a (159) | 4391-a (332) | |
↵1-a P ≤ .05 compared with IgG mAb. See text for details.
Values are mean (S.D.).