Table 2

Mean MDZ product ratios

IntestineLiver
MDZ1-OH/4-OHMDZ1-OH/4-OH
CYP3A5−CYP3A5+CYP3A5−CYP3A5+
μM μM
0.258.312.60.2510.224.0
(0.8)(2.5)(1.3)(11.9)
18.511.019.823.5
(0.4)(1.0)(1.2)(9.8)
47.09.747.816.8
(0.2)(2.1)(0.8)(5.7)
85.77.886.212.3
(0.1)(1.7)(0.6)(3.5)
  • Standard deviations are shown in parentheses.